Endocrine Abstracts

Context: Obesity, diabetes and cardiovascular disease in men are associated with low testosterone levels. Leptin is produced in adipose tissue in proportion to obesity and is known to be negatively associated with testosterone in men. The shared association of testosterone and leptin with obesity is in line with the proposed adipocytokine–hypogonadal–obesity cycle which aims to explain the relationships between these variables.Methods: We inves...

Low testosterone levels are a common in men with coronary artery disease and Type 2 diabetes (DM2). Testosterone replacement therapy improves insulin sensitivity and glycaemic control in men with diabetes and improves numerous other cardiovascular risk factors. Interest in testosterone as a potential treatment for cardiovascular disease continues to grow. Low HDL cholesterol (HDL-C) levels are recognised as an independent cardiovascular risk factor and comprise part of the met...

Men with Type 2 diabetes have a high prevalence of low testosterone levels. Testosterone replacement therapy (TRT) has been shown to improve insulin sensitivity and glycaemic control in men with Type 2 diabetes. TRT also reduces fat mass and central obesity. The androgen receptor CAG repeat polymorphism length (AR CAG) correlates positively with transcriptional activity of the receptor as well as body fat, and insulin levels in healthy men. Most studies have not found an assoc...

Sex hormones are important determinant of body composition. The significant negative correlation between testosterone and obesity, positive correlation between testosterone and muscle mass and that testosterone therapy increases muscle mass in hypogonadal men is well-known.Objectives: To assess the impact of total testosterone (TT) level on body composition in men with T2D.Methods: A cross-sectional study involving men with T2D (<e...

Introduction: Both low testosterone levels and erectile dysfunction (ED) are highly prevalent in men with type 2 diabetes. Lower testosterone levels are known to be associated with worsening severity of ED as assessed using the International Index of Erectile Function score (IIEF). Testosterone deficiency and erectile dysfunction are both independently correlated with increased risk of cardiovascular disease.Aim: To investigate the effect of low testoste...

Aims & objectives: IMPROVE™ is a 6-month, multi-national, prospective, observational study, assessing the safety and efficacy of biphasic insulin aspart 30/70 (BiAsp 30) in patients with type 2 diabetes.Methods: We present the efficacy data from the Indian cohort of IMPROVE study. A total of 17 995 subjects entered the study and 16 942 subjects completed the study. BiAsp 30 was initiated and dose was adjusted at the physician’s discretion, ...

There is a high prevalence of low testosterone levels in men with type 2 diabetes (DM2) and low testosterone predates the onset of DM2. Testosterone replacement therapy for hypogonadal men with DM2 improves insulin sensitivity and glycaemic control as well as reducing central obesity. This may lead to an increase in biochemical assessment of hypogonadism in men with DM2. Androgens and other steroid hormones are produced from cholesterol and it has been postulated that treatmen...

Low testosterone levels are a common finding in men with coronary artery disease and Type 2 diabetes and predict the future development of the metabolic syndrome and Type 2 diabetes in healthy men. Testosterone replacement therapy has been shown to improve insulin sensitivity and glycaemic control in men with diabetes and improves numerous other cardiovascular risk factors. Interest in testosterone as a potential treatment for cardiovascular disease continues to grow. Low HDL ...